Compile Data Set for Download or QSAR

Found 758 hits of ic50 data for polymerid = 482,50000452   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551191 (3-(7-Chloro-1H-indazol-5-yl)-2-cyclobutyl-5-(trifl...) Show SMILES FC(F)(F)c1ccc2nc(C3CCC3)n(-c3cc(Cl)c4[nH]ncc4c3)c2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00500	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551190 (3-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-5-(trif...) Show SMILES FC(F)(F)c1ccc2nc(C3CC3)n(-c3cc(Cl)c4[nH]ncc4c3)c2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00500	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551115 (3-(7-Chloro-1H-indazol-5-yl)-5-(difluoromethyl)-2-...) Show SMILES FC(F)c1ccc2nc(-c3ccc(F)cc3)n(-c3cc(Cl)c4[nH]ncc4c3)c2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551252 (2-Isopropyl-1-(7-methyl-1H-indazol-5-yl)-6-(triflu...) Show SMILES CC(C)c1cc2ccc(nc2n1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551251 (7-Fluoro-5-[2-isopropyl-6-(trifluoromethyl)pyrrolo...) Show SMILES CC(C)c1cc2ccc(nc2n1-c1cc2CC(=O)Nc2c(F)c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00800	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551073 (3-(7-Bromo-1H-indazol-5-yl)-2-isopropyl-5-(trifluo...) Show SMILES CC(C)c1nc2ccc(nc2n1-c1cc(Br)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551213 (7-Methyl-5-(2-methyl-6-(trifluoromethyl)-1H-pyrrol...) Show SMILES Cc1cc2ccc(nc2n1-c1cc2CC(=O)Nc2c(C)c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551218 (5-[2-(Difluoromethyl)-6-(trifluoromethyl)pyrrolo[2...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-n1c(cc2ccc(nc12)C(F)(F)F)C(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288255 (7-Chloro-5-(2-isopropyl-6-(trifluoromethyl)pyrazol...) Show SMILES CC(C)c1cc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C18H14ClF3N4/c1-9(2)15-7-12-3-4-13(18(20,21)22)17(26(12)25-15)10-5-11-8-23-24-16(11)14(19)6-10/h3-9H,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551075 (3-(7-Bromo-1H-indazol-5-yl)-2,5-bis(trifluoromethy...) Show SMILES FC(F)(F)c1nc2ccc(nc2n1-c1cc(Br)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551256 (1-(7-Chloro-1H-indazol-5-yl)-2-methyl-6-(trifluoro...) Show SMILES Cc1cc2ccc(nc2n1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551277 (5-[2-Isopropyl-6-(trifluoromethyl)pyrrolo[2,3-b]py...) Show SMILES CC(C)c1cc2ccc(nc2n1-c1ccc2NC(=O)Cc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288248 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES FC(F)(F)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C17H8ClF6N3O/c18-11-4-8(3-7-5-13(28)25-14(7)11)15-10(16(19,20)21)2-1-9-6-12(17(22,23)24)26-27(9)15/h1-4,6H,5H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0130	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551083 (2-(4-Fluorophenyl)-3-(7-methyl-1H-indazol-5-yl)-5-...) Show SMILES Cc1cc(cc2cn[nH]c12)-n1c(nc2ccc(nc12)C(F)(F)F)-c1ccc(F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288254 (5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...) Show SMILES CC(C)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C19H15ClF3N3O/c1-9(2)15-8-12-3-4-13(19(21,22)23)18(26(12)25-15)11-5-10-7-16(27)24-17(10)14(20)6-11/h3-6,8-9H,7H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0130	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288253 (5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...) Show SMILES CC(C)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(C)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C20H18F3N3O/c1-10(2)16-9-14-4-5-15(20(21,22)23)19(26(14)25-16)13-6-11(3)18-12(7-13)8-17(27)24-18/h4-7,9-10H,8H2,1-3H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288247 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H11F6N3O/c1-8-4-10(5-9-6-14(28)25-15(8)9)16-12(17(19,20)21)3-2-11-7-13(18(22,23)24)26-27(11)16/h2-5,7H,6H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288246 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C17H10F6N4/c1-8-4-9(5-10-7-24-25-14(8)10)15-12(16(18,19)20)3-2-11-6-13(17(21,22)23)26-27(11)15/h2-7H,1H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288245 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES FC(F)(F)c1cc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C16H7ClF6N4/c17-11-4-7(3-8-6-24-25-13(8)11)14-10(15(18,19)20)2-1-9-5-12(16(21,22)23)26-27(9)14/h1-6H,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288302 (7-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2-...) Show SMILES FC(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C16H8ClF5N4/c17-11-4-7(3-8-6-23-24-13(8)11)14-10(15(18)19)2-1-9-5-12(16(20,21)22)25-26(9)14/h1-6,15H,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551163 (3-(7-Bromo-1H-indazol-5-yl)-2-(difluoromethyl)-5-(...) Show SMILES FC(F)c1nc2ccc(nc2n1-c1cc(Br)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551150 (3-(7-Chloro-1H-indazol-5-yl)-2-(1,1-difluoroethyl)...) Show SMILES CC(F)(F)c1nc2ccc(nc2n1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551114 (5-(Difluoromethyl)-2-(4-fluorophenyl)-3-(7-methyl-...) Show SMILES Cc1cc(cc2cn[nH]c12)-n1c(nc2ccc(nc12)C(F)F)-c1ccc(F)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551217 (1-(1H-Indazol-5-yl)-2-isopropyl-6-(trifluoromethyl...) Show SMILES CC(C)c1cc2ccc(nc2n1-c1ccc2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551199 (3-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-5-(triflu...) Show SMILES CC(C)c1nc2ccc(nc2n1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551237 (6-(2-Methyl-6-(trifluoromethyl)-1H-pyrrolo[2,3-b]p...) Show SMILES Cc1cc2ccc(nc2n1-c1ccc2[nH]c(=O)sc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551238 (1-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-pyrrolo[2...) Show SMILES CC(C)c1cc2cccnc2n1-c1cc(Cl)c2[nH]ncc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551153 (3-(7-Chloro-1H-indazol-5-yl)-2,5-bis(trifluorometh...) Show SMILES FC(F)(F)c1nc2ccc(nc2n1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551030 (3-(7-Bromo-1H-indazol-5-yl)-2-cyclobutyl-5-(triflu...) Show SMILES FC(F)(F)c1ccc2nc(C3CCC3)n(-c3cc(Br)c4[nH]ncc4c3)c2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551188 (3-(7-(Prop-1-en-2-yl)-1H-indazol-5-yl)-2,5-bis(tri...) Show SMILES CC(=C)c1cc(cc2cn[nH]c12)-n1c(nc2ccc(nc12)C(F)(F)F)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288250 (5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...) Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1 Show InChI InChI=1S/C19H13ClF3N3O/c20-14-6-11(5-10-7-16(27)24-17(10)14)18-13(19(21,22)23)4-3-12-8-15(9-1-2-9)25-26(12)18/h3-6,8-9H,1-2,7H2,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551177 (3-(7-Methyl-1H-indazol-5-yl)-2,5-bis(trifluorometh...) Show SMILES Cc1cc(cc2cn[nH]c12)-n1c(nc2ccc(nc12)C(F)(F)F)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288303 (6-(Difluoromethyl)-7-(7-methyl-1H-indazol-5-yl)-2-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)F Show InChI InChI=1S/C17H11F5N4/c1-8-4-9(5-10-7-23-24-14(8)10)15-12(16(18)19)3-2-11-6-13(17(20,21)22)25-26(11)15/h2-7,16H,1H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551280 (5-[2-Cyclopropyl-6-(trifluoromethyl)pyrrolo[2,3-b]...) Show SMILES FC(F)(F)c1ccc2cc(C3CC3)n(-c3ccc4NC(=O)Cc4c3)c2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551249 (5-[2-Isopropyl-6-(trifluoromethyl)pyrrolo[2,3-b]py...) Show SMILES CC(C)c1cc2ccc(nc2n1-c1cc2CC(=O)Nc2c(C)c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551197 (3-(7-Chloro-1H-indazol-5-yl)-2-ethyl-5-(trifluorom...) Show SMILES CCc1nc2ccc(nc2n1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551239 (7-Chloro-5-(2-isopropylpyrrolo[2,3-b]pyridin-1-yl)...) Show SMILES CC(C)c1cc2cccnc2n1-c1cc2CC(=O)Nc2c(Cl)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551254 (1-(7-Chloro-1H-indazol-5-yl)-2-(3-fluoropropyl)-6-...) Show SMILES FCCCc1cc2ccc(nc2n1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551282 (5-[2-Isopropyl-6-(trifluoromethyl)pyrrolo[2,3-b]py...) Show SMILES CC(C)c1cc2ccc(nc2n1-c1cnc2NC(=O)Cc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551011 (2-Cyclobutyl-3-(1H-indazol-5-yl)-5-isopropyl-imida...) Show SMILES CC(C)c1ccc2nc(C3CCC3)n(-c3ccc4[nH]ncc4c3)c2n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551136 (3-(7-Chloro-1H-indazol-5-yl)-2-(3-fluorocyclobutyl...) Show SMILES F[C@H]1C[C@@H](C1)c1nc2ccc(nc2n1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F |r,wU:3.5,wD:1.0,(6.48,2.77,;4.94,2.77,;3.85,3.86,;2.76,2.77,;3.85,1.68,;1.22,2.77,;.32,4.02,;-1.15,3.54,;-2.48,4.31,;-3.81,3.54,;-3.81,2,;-2.48,1.23,;-1.15,2,;.32,1.52,;.72,.04,;-.37,-1.05,;.03,-2.54,;-1.06,-3.63,;1.51,-2.94,;2.21,-4.31,;3.73,-4.07,;3.97,-2.55,;2.6,-1.85,;2.2,-.36,;-5.15,1.23,;-6.48,2,;-5.15,2.77,;-5.15,-.31,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551141 (2-Cyclopropyl-3-(7-methyl-1H-indazol-5-yl)-5-(trif...) Show SMILES Cc1cc(cc2cn[nH]c12)-n1c(nc2ccc(nc12)C(F)(F)F)C1CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551152 (3-(7-Chloro-1H-indazol-5-yl)-5-(difluoromethyl)-2-...) Show SMILES CC(C)c1nc2ccc(nc2n1-c1cc(Cl)c2[nH]ncc2c1)C(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551165 (6-[2,5-Bis(trifluoromethyl)imidazo[4,5-b]pyridin-3...) Show SMILES FC(F)(F)c1nc2ccc(nc2n1-c1cc(Cl)c2[nH]c(=O)sc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551086 (2-Isopropyl-3-(7-methyl-1H-indazol-5-yl)-5-(triflu...) Show SMILES CC(C)c1nc2ccc(nc2n1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551209 (5-(Difluoromethyl)-3-(7-methyl-1H-indazol-5-yl)-2-...) Show SMILES Cc1cc(cc2cn[nH]c12)-n1c(nc2ccc(nc12)C(F)F)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551214 (5-(2-Isopropyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-7-me...) Show SMILES CC(C)c1cc2cccnc2n1-c1cc(C)c2[nH]ncc2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551216 (5-[6-(Difluoromethyl)-2-isopropyl-pyrrolo[2,3-b]py...) Show SMILES CC(C)c1cc2ccc(nc2n1-c1cc2CC(=O)Nc2c(C)c1)C(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288237 (6-(4-Fluorophenyl)-5-(7-methyl-1H-indazol-5-yl)-2-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H13F4N5/c1-11-8-13(9-14-10-26-28-18(11)14)19-16(12-2-4-15(22)5-3-12)6-7-17-27-20(21(23,24)25)29-30(17)19/h2-10H,1H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM551253 (2-(3-Fluoropropyl)-1-(7-methyl-1H-indazol-5-yl)-6-...) Show SMILES Cc1cc(cc2cn[nH]c12)-n1c(CCCF)cc2ccc(nc12)C(F)(F)F Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2K93BR4
					More data for this Ligand-Target Pair

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